Selank: Detailed Introduction & Benefits

1. Basic Profile

Selank (Russian: Селанк) is a synthetic heptapeptide (7 amino acids: Thr-Lys-Pro-Arg-Pro-Gly-Pro, TKPRPGP), developed by the Institute of Molecular Genetics, Russian Academy of Sciences.

• Class: Nootropic, anxiolytic, immunomodulatory peptide
• Molecular weight: ~751.89 Da
• Half-life: Very short (2–10 minutes; rapid but stable effects via receptor modulation)
• Origin: Synthetic analog of tuftsin (a natural immunomodulatory peptide from IgG antibodies), optimized for stability and dual neuro-immune activity
• Status: Approved prescription drug in Russia (since early 2000s) for anxiety, neurasthenia, and stress-related disorders.

2. Core Mechanism of Action

Selank acts on CNS + immune system via multiple pathways, without sedation or dependence:

1. GABAergic modulation (anxiolysis)

   • Indirectly enhances GABA-A receptor sensitivity and GABA levels (inhibits GABA-degrading enzymes).
   • Unlike benzodiazepines, it does not cause sedation, amnesia, or tolerance.

2. Serotonergic & monoamine balance (mood + focus)

   • Modulates 5-HT₁A receptors and serotonin metabolism; stabilizes mood and reduces anxiety.
   • Boosts dopamine/norepinephrine in prefrontal cortex → improves attention, motivation, and stress resilience.

3. BDNF upregulation (neuroplasticity + cognition)

   • Rapidly elevates BDNF (Brain-Derived Neurotrophic Factor) in the hippocampus → supports neuronal growth, memory consolidation, and learning.

4. Enkephalin protection (stress relief + comfort)

   • Inhibits enzymes that break down enkephalins (endogenous anti-stress peptides) → prolongs natural calm and reduces emotional reactivity.

5. Immunomodulation (anti-inflammatory + antiviral)

   • Balances cytokines (IL-6, TNF-α); shifts immunity to anti-inflammatory phenotype.
   • Enhances NK cell/macrophage activity; shows antiviral effects (influenza, HSV, CMV).

3. Key Benefits & Uses

① Anxiolytic (Anti-Anxiety) – Non-Sedating

• Generalized anxiety, social anxiety, PTSD: Reduces worry, anticipatory stress, and panic-like symptoms; comparable to low-dose benzodiazepines but no sedation or dependence.
• Stress resilience: Blunts stress-induced cortisol spikes; improves emotional stability under pressure.
• Public speaking/performance anxiety: Calms nerves without mental fog.

② Nootropic (Cognitive Enhancement)

• Memory & learning: Improves memory consolidation, verbal learning, and recall (via BDNF).
• Attention & focus: Enhances sustained attention, mental clarity, and task performance.
• Mental fatigue: Reduces brain fog and asthenia (weakness/exhaustion) from chronic stress.

③ Mood & Emotional Well-Being

• Mild depression & anhedonia: Elevates mood and motivation; complements antidepressants.
• Emotional regulation: Reduces irritability, mood swings, and overreaction.

④ Immune Support & Anti-Inflammation

• Chronic stress-induced immune suppression: Restores immune balance.
• Viral infections: Adjunct for influenza, herpes, and other viral illnesses.
• Low-grade inflammation: Modulates inflammatory cytokines; supports recovery.

⑤ Neuroprotection & Anti-Aging

• Neurodegenerative support: BDNF upregulation protects neurons from ischemia/excitotoxic damage.
• Brain aging: Preserves cognitive function and emotional stability in aging populations.

⑥ Addiction & Withdrawal Adjunct

• Reduces anxiety and cravings during alcohol/benzodiazepine withdrawal; no substitution liability.

4. Administration & Safety

• Routes:
  • Intranasal (IN): Most common; fast onset (~30 min).
  • Subcutaneous (SC): Longer-lasting; 1–2× daily.
• Typical dose: 250–500 mcg/day; 1–3 doses; cycles of 14–21 days.
• Side effects: Mild & rare (transient headache, mild nasal irritation; no severe toxicity).
• Advantages over benzodiazepines: No sedation, no memory loss, no tolerance, no withdrawal, no dependence.

5. Summary

Selank is a unique neuro-immune peptide with anxiolytic + nootropic + immunomodulatory triple benefits. It delivers calm, focus, and mood balance without sedation or dependence, while supporting immunity and brain health. Ideal for stress, anxiety, cognitive decline, and immune imbalance.

Research Use Only. This catalog information is reproduced from the customer legacy website. Products are not for human or veterinary use. Confirm current specification, availability and documentation before ordering.