5‑Amino‑1MQ – Full Details & Benefits

1. Basic Introduction

5‑Amino‑1MQ (full name: 5‑Amino‑1‑methylquinolinium; abbreviations: 5A1MQ / NNMTi) is a potent, selective small‑molecule inhibitor of the enzyme NNMT (nicotinamide N‑methyltransferase). It is not a peptide—a synthetic quinolinium‑class compound designed to reset cellular metabolism by blocking the “methyl sink” pathway.

• CAS: 42464‑96‑0
• Molecular weight: ~159.6 Da
• Form: Lyophilized white powder (injectable) or oral capsule
• Purity: ≥99% HPLC (research grade)
• Key target: NNMT (highly expressed in fat, liver, muscle)
• Status: Preclinical research compound (not FDA/EMA approved for human use

2. Core Mechanism of Action (NNMT Inhibition)

NNMT is an enzyme that drains cellular energy: it uses SAM (methyl donor) to convert nicotinamide (NAM) into 1‑MNA, which depletes NAD⁺ and drives fat storage, insulin resistance, and aging.

5‑Amino‑1MQ blocks NNMT → 3 critical shifts:

1. NAD⁺ Restoration: NAM is redirected to the NAD⁺ salvage pathway → higher NAD⁺ levels.
2. Sirtuin Activation: NAD⁺ fuels SIRT1/SIRT3 → boosts mitochondrial function & fat oxidation.
3. Reduced Lipogenesis: Blocks new fat cell formation & shrinks adipocyte size.

Unique advantage: Works via metabolic rewiring, not appetite suppression (unlike GLP‑1s).

3. Key Benefits (Preclinical Research Proven)

1. Powerful Fat Loss & Body Recomposition

• Reduces visceral & white fat (without lowering food intake).
• Shrinks adipocytes & inhibits new fat formation (lipogenesis).
• Preserves lean muscle—no muscle loss during fat loss.
• In rodents: −5–8% body weight in 4–6 weeks via higher energy expenditure.

2. Metabolic Health & Insulin Sensitivity

• Lowers fasting glucose & HbA1c; improves glucose tolerance.
• Reduces insulin resistance (lower HOMA‑IR) → supports type 2 diabetes research.
• Lowers liver fat (NAFLD/MAFLD) & hepatic inflammation.

3. NAD⁺ Boost & Longevity Support

• Elevates NAD⁺ (critical for energy, DNA repair, anti‑aging).
• Activates sirtuins (SIRT1/3) → delays cellular senescence & improves skin elasticity.
• Enhances mitochondrial biogenesis (PGC‑1α upregulation) → more efficient energy production.

4. Muscle & Physical Performance

• Reverses sarcopenia (age‑related muscle loss) in aged models.
• Increases endurance & VO₂ max—exercise‑mimetic effects.
• Speeds recovery from training/injury via reduced oxidative stress.

5. Neuroprotection & Cognitive Support

• Improves mitochondrial function in neurons → supports memory & focus.
• Anti‑inflammatory in brain tissue → potential for neurodegenerative research.

4. Safety & Research Notes

• Well‑tolerated in preclinical models; no severe adverse effects at standard research doses.
• No hypoglycemia risk (unlike insulin/GLP‑1s).
• Common mild effects: transient headaches, mild GI upset (rare).
• Research use only: Not approved for human medical treatment.

5. Summary

5‑Amino‑1MQ is a next‑generation metabolic small molecule that targets NNMT to restore NAD⁺, activate sirtuins, and drive fat loss while preserving muscle. It offers a unique appetite‑independent approach to body recomposition, metabolic health, and longevity—ideal for research into obesity, insulin resistance, fatty liver, and age‑related decline.

Research Use Only. This catalog information is reproduced from the customer legacy website. Products are not for human or veterinary use. Confirm current specification, availability and documentation before ordering.