AOD9604 – Full Details & Benefits

1. Basic Introduction

AOD9604 is a synthetic 16‑amino‑acid peptide derived from the C‑terminal fragment (aa 176–191) of human growth hormone (hGH). A tyrosine is added at the N‑terminus for stability, and a disulfide bond between two cysteines makes it cyclic.

• Other names: hGH Frag 176–191 (modified)
• Molecular formula: C₇₈H₁₂₃N₂₃O₂₃S₂
• Molecular weight: ~1,815 Da (free base)
• Appearance: White lyophilized powder
• Purity: ≥98% (HPLC)
• Classification: Lipolytic / metabolic peptide (research use only)
• Key feature: Mimics GH’s fat‑burning effects without raising IGF‑1 or disrupting glucose/insulin.

2. Mechanism of Action

AOD9604 works mainly via beta‑3 adrenergic receptors (β₃‑AR) in fat cells:

1. Upregulates β₃‑AR → adipocytes become more sensitive to fat‑breakdown signals.
2. Activates cAMP‑PKA‑HSL cascade → triggers hormone‑sensitive lipase (HSL) → breaks down stored triglycerides into free fatty acids (FFAs).
3. Inhibits acetyl‑CoA carboxylase (ACC) → reduces new fat synthesis (lipogenesis).
4. No IGF‑1 stimulation → no anabolic/muscle growth side effects of full hGH.
5. No insulin resistance / blood sugar spikes → safer metabolic profile.

3. Main Benefits & Effects

1. Targeted Fat Loss (Lipolysis)

• Burns stubborn subcutaneous & visceral fat (abdomen, hips, thighs).
• Preferentially targets obese adipocytes over lean ones.
• In clinical trials: ~1.8–2.6 kg fat loss over 12 weeks (1 mg/day) vs. placebo.

2. Boosts Resting Metabolism & Energy

• Increases basal energy expenditure → burn more calories at rest.
• Enhances fat oxidation → uses FFAs for fuel.

3. Preserves Lean Muscle Mass

• Fat loss without muscle loss (no IGF‑1 = no muscle growth, but no catabolism either).
• Good for body recomposition (fat down, muscle stable).

4. Metabolic Safety (vs. hGH)

• No IGF‑1 elevation → avoids acromegaly risk.
• No glucose/insulin disruption → safe for insulin‑sensitive users.
• No impact on natural hormone feedback.

5. Joint & Cartilage Support (Research)

• Preclinical data: may enhance proteoglycan synthesis → supports osteoarthritis repair.

4. Dosage & Administration (Research Use)

• Standard dose: 250–500 mcg subcutaneous injection (abdomen/thigh) once daily.
• Cycle length: 4–12 weeks; 4–8 weeks off before repeating.
• Reconstitution: Mix with bacteriostatic water (1–2 mg/mL).

5. Safety & Side Effects

Common Mild (Transient)

• Mild injection site redness/itching.
• Slight headache or lightheadedness (rare).
• No flu‑like symptoms (unlike some peptides).

Key Safety Advantages

• No IGF‑1 surge → safe long‑term (research).
• No insulin resistance → suitable for metabolic management.
• Non‑addictive, no hormonal dependency.

Warnings

• Not approved by FDA for human use (research only).
• Banned in competitive sports (WADA list).
• Not for pregnant/nursing women or children.

6. Summary

AOD9604 is a selective lipolytic peptide that delivers GH‑like fat loss without IGF‑1 or glucose side effects. Its core benefits are targeted fat reduction, higher resting metabolism, and lean muscle preservation, making it popular in peptide research for weight management and body recomposition.

Research Use Only. This catalog information is reproduced from the customer legacy website. Products are not for human or veterinary use. Confirm current specification, availability and documentation before ordering.