SS-31 (Elamipretide / Bendavia / MTP‑131) – Detailed Introduction & Benefits

Basic Introduction

SS‑31 (generic name: Elamipretide) is a synthetic, mitochondria‑targeted tetrapeptide (4 amino acids) developed by Szeto and Schiller (Szeto–Schiller peptide, SS peptide).

• Sequence: D‑Arg‑Dmt‑Lys‑Phe‑NH₂ (Dmt = 2′,6′‑dimethyltyrosine)
• Molecular weight: 639.8 g/mol
• Other names: Bendavia, MTP‑131
• Key feature: Selectively accumulates ~1,000–5,000‑fold in the inner mitochondrial membrane (IMM) versus cytoplasm, without needing energy or receptors.
• Solubility: Water‑soluble, stable in solution, resistant to peptidase degradation.
• Clinical stage: Multiple Phase 3 trials; FDA accelerated approval in 2025 for certain mitochondrial disorders.

Mechanism of Action

1. Targets & binds cardiolipin (a unique IMM phospholipid critical for electron transport chain (ETC) function).
2. Stabilizes ETC structure：Optimizes electron flow, boosts ATP synthesis, and blocks ROS production at the source (unlike traditional antioxidants that only scavenge existing free radicals).
3. Prevents oxidative damage：Inhibits cardiolipin peroxidation, maintains mitochondrial membrane potential (ΔΨm), and blocks cytochrome c release (anti‑apoptotic).
4. Restores mitochondrial cristae：Improves structure and function of damaged/aged mitochondria.
5. Supports mitochondrial biogenesis：May promote new mitochondria formation.

Main Benefits

1. Mitochondrial Protection & Energy Boost

• Increases ATP production：Enhances oxidative phosphorylation, raises cellular energy levels.
• Reduces ROS & oxidative stress：Lowers free radical damage, protects DNA, proteins, and lipids.
• Preserves membrane potential：Maintains mitochondrial integrity under stress or aging.

2. Anti‑Aging & Longevity

• Reduces cellular senescence：Delays age‑related decline in organ function.
• Improves tissue regeneration：Enhances repair of aged/damaged cells and organs.
• Extends healthspan：Supports youthful metabolism and physical resilience.

3. Cardiac Health

• Improves heart failure symptoms：Enhances cardiac output and exercise tolerance.
• Protects cardiomyocytes：Reduces ischemia/reperfusion injury and fibrosis.
• Supports heart function in aging：Prevents age‑related cardiac decline.

4. Physical Performance & Recovery

• Boosts endurance：Increases exercise capacity and oxygen utilization.
• Reduces muscle fatigue：Lowers lactate buildup and improves recovery time.
• Speeds injury repair：Accelerates recovery from muscle, tendon, and joint damage.

5. Cognitive & Neurological Support

• Crosses blood‑brain barrier (BBB)：Directly protects brain mitochondria.
• Enhances cognitive function：Supports memory, focus, and mental clarity.
• Neuroprotective：Reduces risk of age‑related neurodegeneration (e.g., Alzheimer’s).

6. Organ Protection

• Kidney：Improves glomerular structure, reduces fibrosis, protects against age‑related kidney disease.
• Liver：Supports detoxification and reduces oxidative injury.
• Eyes：Beneficial for age‑related macular degeneration (AMD) and retinal atrophy.

7. Metabolic Health

• Supports fat loss：Enhances mitochondrial fat oxidation and metabolic efficiency.
• Improves insulin sensitivity：Helps regulate blood glucose and reduce diabetes risk.

Key Advantages Over Traditional Antioxidants

• Targets the source: Prevents ROS production at the ETC, not just scavenges after damage.
• Mitochondria‑specific: No off‑target effects on healthy cells.
• Clinically validated: Over 150 peer‑reviewed studies and multiple Phase 3 trials.

Common Uses

• Longevity & anti‑aging
• Mitochondrial dysfunction support
• Heart health & recovery
• Athletic performance & muscle repair
• Cognitive enhancement & neuroprotection
• Kidney, liver, and eye health support

Research Use Only. This catalog information is reproduced from the customer legacy website. Products are not for human or veterinary use. Confirm current specification, availability and documentation before ordering.